Distributed Asymmetric Virtual Reality in Industrial Context: Enhancing the Collaboration of Geographically Dispersed Teams in the Pipeline of Maintenance Method Development and Technical Documentation Creation

Featured ApplicationBased on data from multinational domain experts in the field of Industrial Maintenance, this study demonstrated the application cases and advantages of asymmetric VR set-up to address needs present in the industry.Virtual Reality (VR) is a critical emerging technology in industrial contexts, as it facilitates collaboration and supports the product development lifecycle. However, its broad adoption is constrained by complex and high-cost integration. The use of VR among devices with various immersion and control levels may solve this obstacle, and increase the scalability of VR technologies. This article presents a case study on applying asymmetry between the COVE-VR platform and Microsoft Teams to enable distributed collaboration of multinational departments and enhance the maintenance method and documentation creation processes. Overall, five remote collaborative sessions were held with 20 experts from four countries. Our findings suggest that asymmetry between head-mounted display and Teams users enhances the quality of communication among geographically dispersed teams and their spatial understanding, which positively influences knowledge transfer and efficiency of industrial processes. Based on qualitative evaluation of the asymmetric VR setup, we further suggest a list of guidelines on how to enhance the collaboration efficiency for low-cost distributed asymmetric VR from three perspectives: organization, collaboration and technology.

Design, Synthesis, and In Vivo Evaluation of C1-Linked 4,5-Epoxymorphinan Haptens for Heroin Vaccines.

In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap (1), 1-AmidoMorHap epimer (2), 1 Amido-DihydroMorHap (3), and 1 Amido-DihydroMorHap epimer (4). This is the first report of hydrolytically stable haptenic surrogates of heroin with the attachment site at the C1 position in the 4,5-epoxymorophinan nucleus. We prepared respective tetanus toxoid (TT)-hapten conjugates as heroin vaccine immunogens and evaluated their efficacy in vivo. We showed that all TT-hapten conjugates induced high antibody endpoint titers against the targets but only haptens 2 and 3 can induce protective effects against heroin in vivo. The epimeric analogues of these haptens, 1 and 4, failed to protect mice from the effects of heroin. We also showed that the in vivo efficacy is consistent with the results of the in vitro drug sequestration assay. Attachment of the linker at the C1 position induced antibodies with weak binding to the target drugs. Only TT-2 and TT-3 yielded antibodies that bound heroin and 6-acetyl morphine. None of the TT-hapten conjugates induced antibodies that cross-reacted with morphine, methadone, naloxone, or naltrexone, and only TT-3 interacted weakly with buprenorphine, and that subtle structural difference, especially at the C6 position, can vastly alter the specificity of the induced antibodies. This study is an important contribution in the field of vaccine development against small-molecule targets, providing proof that the chirality at C6 in these epoxymorphinans is a vital key to their effectiveness.

Multi-User Virtual Reality for Remote Collaboration in Construction Projects: A Case Study with High-Rise Elevator Machine Room Planning

Virtual Reality (VR) is considered among the major technologies to address the inefficient collaboration issue caused by the predominant use of 2D drawings in the construction industry. However, there is still a knowledge gap between researchers and practitioners about the actual benefits of VR in the business context. This paper presents the benefits of VR usage in four real-life high-rise elevator projects from the user and business perspectives. Four VR environments of actual machine rooms for planning were created and tested in a multi-user setting. Overall, users find VR more intuitive than conventional tools to enhance planning accuracy and collaboration. The results also show that VR brings significant economic savings and gains for business in the industry. Future study should investigate the real cost-benefit ratio of VR and streamline its technical implementation within construction projects. The research contributes to the current body of knowledge by providing real-life economic benefits and directions to address the research gap in both academia and industry to promote the wide adoption of VR.

There is Always a Way: Organizing VR User Tests with Remote and Hybrid Setups during a Pandemic—Learnings from Five Case Studies

(1) COVID-19 pandemic restrictions caused a dramatic shift in research activities, forcing the adoption of remote practices and methods. Despite the known benefits of remote testing, there is limited knowledge on how to prepare and conduct such studies in the industrial context where the target users are experts and company employees. (2) In this article, we detail how we organized VR user tests in five industrial cases during the pandemic, focusing on practicalities and procedures. We cover both on-site testing, including disinfecting and other safety protocols, as well as remote and hybrid setups where both remote and on-site participants were involved. Subject matter experts from eight countries were involved in a total of 22 tests. (3) We share insights for VR user test arrangements relevant to the pandemic, remote and hybrid setups, and an industrial context, among others. (4) Our work confirms that with careful planning it is possible to organize user tests remotely. There are also some limitations in remote user testing, such as reduced visibility and interaction with participants. Most importantly, we list practical recommendations for organizing hybrid user tests with safety and disinfecting procedures for on-site VR use.